Organic Chemistry

Advances in Medicinal Chemistry: 4 by B. E. Maryanoff,A. B. Reitz

By B. E. Maryanoff,A. B. Reitz

quantity four of Advances in Medicinal Chemistry is created from six chapters on a variety of themes in medicinal chemistry, together with molecular modeling, structure-based drug layout, natural synthesis, peptide conformational research, organic overview, structure-activity correlation, and lead optimization. bankruptcy 1 offers an account approximately amino acid-based peptide mimetics reminiscent of b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. bankruptcy 2 addresses new elements of the medicinal chemistry of the real anticancer drug Taxol® (paclitaxel). bankruptcy three relates an account of the hunt for brand new medications for the remedy of malaria in accordance with the typical product artemisinin. bankruptcy four applies computational chemistry to the review of compound libraries for organic trying out. bankruptcy five describes the development of a third-dimensional molecular version of the human thrombin receptor, the 1st protease-activated G-protein coupled receptor (PAR-1), as a method to discover the intermolecular contacts all in favour of agonist peptide attractiveness. eventually, bankruptcy 6 describes the study carried out at Merck on inhibitors of farnesyl transferase as a possible therapy for human cancers.

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